Tottenham host RB Leipzig in the first leg of their Champions League Round of 16 tie. The Tottenham Hotspur Stadium has seen more goals than any other venue in this season's UCL.
Atalanta face Valencia in the first leg of their UEFA Champions League Round of 16 tie at the San Siro. This will be the first ever encounter between the two sides.
Chelsea and Tottenham go head-to-head in the Premier League as they meet at Stamford Bridge.
Brendan Rodgers's Leicester City welcome Premier League champions Manchester City to the King Power Stadium. Pep Guardiola's side ran out 3-1 winners when the sides met earlier this season.
Mikel Arteta's Arsenal welcome another of his former clubs - Everton - to the Emirates Stadium in the Premier League. A tightly fought reverse fixture at Goodison ended 0-0.