Arsenal face a tricky test of their top-four credentials as they visit Bramall Lane to take on Chris Wilder's Sheffield United in Monday Night Football from the Premier League.
Manchester City welcome Atalanta to the Etihad Stadium in Group C of the UEFA Champions League.
Tottenham host Red Star in Group B of the UEFA Champions League at Tottenham Hotspur Stadium.
Action from Group H of the UEFA Champions League as Frank Lampard's Chelsea side travel to the Amsterdam Arena to face Ajax.
Jurgen Klopp's Liverpool side travel to Belgium to face Genk in Group E of the UEFA Champions League at Cristal Arena.